The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1969, 102: 804-811.
Copyright © 1969 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yoshida, T.
Right arrow Articles by Vassalli, P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Yoshida, T.
Right arrow Articles by Vassalli, P.

The Effect of Intravenous Antigen on Circulating Monocytes in Animals with Delayed Hypersensitivity

Takeshi Yoshida1, Baruj Benacerraf, Robert T. McCluskey and Pierre Vassalli2

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland and The Department of Pathology, State University of New York, Buffalo, New York

Abstract

A study was made of the effect of intravenous antigenic challenge on the levels of circulating leukocytes in delayed sensitive rats and guinea pigs.

A sharp decrease in the level of blood monocytes was observed 6 hr after antigenic challenge. This drop was generally followed after 24 hr by a compensatory increase in the number of these cells in the circulation.

The decrease and subsequent rebound of the level of blood monocytes following antigenic challenge was shown to be a systemic manifestation of delayed hypersensitivity and could not be elicited by the passive administration of antibody followed by antigen.

The increase in blood monocytes observed 24 hr after challenge was found to be the result of the release of new cells from the bone marrow.

No effect of antigenic challenge was detected on the levels of circulating lymphocytes or polymorphonuclear cells.

The relationship between these phenomena and in vivo and in vitro manifestations of delayed hypersensitivity is discussed.

Footnotes

1 On leave of absence from The National Institute of Health, Tokyo, Japan.

2 Present address: Department of Pathology, University of Geneva, Geneva, Switzerland.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1969 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1969 by The American Association of Immunologists, Inc. All rights reserved.