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A Study of Immunologic Tolerance in the Dinitrophenyl Poly-l-Lysine Immune System¹

From the Departments of Medicine and Pathology, New York University School of Medicine, New York, New York

Abstract

DNP-PLL genetic "non-responder" guinea pigs made tolerant to BSA by a low dose method exhibit a reduced synthesis of anti-DNP antibody upon immunization with DNP-PLL complexed electrostatically to BSA. The anti-DNP antibody synthesized by such animals is of low affinity as compared with that synthesized by normal "non-responder" guinea pigs.

Footnotes

This study was supported by United States Public Health Service Grants AI-2094 and AM-08805. Computer facilities of the Section on Communication Sciences, Department of Neurosurgery, New York University Medical Center made use of in this study were supported by United States Public Health Service Research Grant FR-00331-01A1.

² Supported by a training grant from the United States Public Health Service (1-F2-AI-33,253).

³ Career Scientists of the Health Research Council of the City of New York under Research Investigatorships I-138 and I-464.

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