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Immunologic Response to Altered Encephalitogenic Protein in Guinea Pigs¹

From the Department of Microbiology, Wayne State University, School of Medicine, Detroit, Michigan 48207

Abstract

The immunologic and pathogenetic properties of diazonium derivatives of a purified highly encephalitogenic basic protein (BP) of rabbit origin were investigated. Ars-Sulf-BP, containing three to four azo groups per molecule, was no longer basic by electrophoretic analysis, although the ultracentrifugal characteristics of the original BP were retained.

Guinea pigs immunized with Ars-Sulf-BP did not develop EAE, although delayed hypersensitivitity to BP could be demonstrated. Similar results were obtained when BP was conjugated with the cationic R₄N group.

Guinea pigs immunized with Ars-Sulf-BP produced antibodies which appeared to be specific for a determinant larger in size than the haptenic group.

Footnotes

This work was supported by Research Grant NB 06985 from the National Institute of Neurological Diseases and Blindness, United States Public Health Service, Bethesda, Maryland.