HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Morse, H. C. Articles by Bloch, K. J. Search for Related Content PubMed Articles by Morse, H. C., III Articles by Bloch, K. J.

Biologic Properties of Rat Antibodies

III. Histamine Release Mediated by Two Classes of Antibodies¹

From the Department of Medicine, Harvard Medical School at the Robert B. Brigham and Massachusetts General Hospitals and the Arthritis Unit of the Medical Services, Massachusetts General Hospital, Boston, Massachusetts

Abstract

Two different classes of rat antibodies have been shown to mediate the i.p. antigen-induced release of histamine. The heat-stable antibodies, associated with IgG_a, involved in histamine release could be clearly differentiated from heat-labile homocytotropic antibodies. Antibodies associated with IgG_a have been previously shown to mediate the antigen-induced release of SRS-A. It was not possible to dissociate the two biologic activities associated with IgG_a antibodies by physical means.

Footnotes

This study was supported by Grants AI-07722, FR-05669, AM-5067, and AM-3564 from the National Institutes of Health; a grant from the New England Peabody Home Foundation; and grants from the Damon Runyon Memorial Fund for Cancer Research and the American Cancer Society, Inc.

² Predoctoral Fellow, Harvard Medical School.

³ Senior Investigator, Arthritis Foundation.

This article has been cited by other articles:

				W. Walker, M Wu, and K. Bloch Stimulation by immune complexes of mucus release from goblet cells of the rat small intestine Science, July 22, 1977; 197(4301): 370 - 372. [Abstract] [PDF]