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Humoral Immunity in Rodent Malaria¹

II. Inhibition of Parasitemia by Serum Antibody

From the Department of Microbiology, The Johns Hopkins University, Baltimore, Maryland

Abstract

Serum from rats actively immune to Plasmodium berghei can inhibit the development of parasitemia and reduce morbidity to a marked extent when administered to normal recipients at the time of challenge. Smaller doses of potent serum, equivalent to less than 0.05% of the recipient's plasma volume, can also reduce parasitemia to a statistically significant extent. The protective activity of hyperimmune serum, which can be measured by a simple passive transfer assay, is primarily associated with the 7 S immunoglobulins. It persists in the circulation for more than 6 months after infection and rapidly increases on restimulation with the infectious agent.

Footnotes

¹ Support for this investigation was provided, in part, by the National Science Foundation, GB-1120; the American Cancer Society, Inc., Grant T-257; the National Institute of Allergy and Infectious Diseases, United States Public Health Service, Grant AI-03151; and the Office of The Surgeon General, Department of the Army, under the auspices of the Commission of Immunization of the Armed Forces Epidemiological Board, Contract DA-49-193-MD-2468.

Presented in part at the Annual Meeting of the American Association of Immunologists, Atlantic City (Fed. Proc., 27: 369, 1968).

² Portion of a dissertation submitted in partial fulfillment of the requirements for the Ph.D. degree. Present address: Chief, Department of Parasitology, USA Medical Component, SEATO, APO, San Francisco, Calif., 96346.

³ Present address: Department of Medical Immunology, The Public Health Research Institute of the City of New York, Inc., New York, N. Y. 10016, to which reprint requests should be addressed.