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Studies on the Mechanism of the Suppression of Active Antibody Synthesis by Passively Administered Antibody¹

From the Department of Medicine, New York University Medical School, New York, New York

Abstract

F(ab')₂ and Fab' anti-DNP antibody fragments suppressed anti-DNP antibody formation. The fraction of anti-DNP antibody elutable from a specific precipitate by p-nitrophenyl--aminocaproic acid (p-NP-EACA) suppressed anti-DNP antibody formation but did not alter the percentage of the anti-DNP antibody that could be eluted with p-NP-EACA.

The data are consistent with the concept that passively tranferred antibody causes suppression by binding antigen thus preventing it from stimulating potential antibody-forming cells.

Footnotes

This study was supported by United States Public Health Service Research Grant 5-R01-AM08805. Computer facilities of the Section on Communication Sciences, Department of Neurosurgery, New York University Medical Center made use of in this study were supported by United States Public Health Service Research Grant FR-00331-01AI.

² Career Scientist of the Health Research Council of the City of New York under Career Scientist Award I-464.