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The Specificity of a Monoclonal Macroglobulin (M) Antibody: Reactivity with Primate G Immunoglobulins¹

From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

A Waldenström macroglobulin antibody (M_Lay) which reacts with human G has been tested with G from the major families of the Primate order. The antibody cannot distinguish between G from the Hominoidea and Cercopithecoidea. It is totally unreactive with G from the Ceboidea but, interestingly, reacts weakly with the more distantly related Lorisiformes (but not with G from the Lemuriformes). Moreover, high molar ratios of G from the Lorisiformes, P. potto and G. crassicaudatus quantitatively precipitated the M_Lay antibody.

These results are most consistent with M_Lay being homogeneous and directed to a single determinant on human G.

Footnotes

¹ Presented in part at the 52nd Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, 1968.

² Present address: Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235.

³ To whom inquiries should be addressed.

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