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Antiserum Neutralization of Bacteriophage Q : A Mathematical Analysis

From the Departments of Molecular Biology and Applied Mathematics, Abbott Laboratories, North Chicago, Illinois 60064

Abstract

The inactivation of the bacteriophage, Q , with specific antiserum was studied. The reaction exhibited a continual decrease in rate that was evident from the beginning. The same limiting value of the surviving fraction was reached by all concentrations of a serum. The deviation from first order kinetics was not attributable to dissociation or pre-existing phage heterogenity. The results support the idea of the development of resistant phages by interaction with antiserum components. The curve of neutralization could be approximated mathematically.