HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Klemperer, M. R. Search for Related Content PubMed Articles by Klemperer, M. R.

Hereditary Deficiency of the Second Component of Complement in Man: An Immunochemical Study¹

From the Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts

Abstract

The sera of four homozygous C'2 deficient individuals and 15 heterozygous C'2 deficient individuals in two kindreds were investigated by immunochemical techniques. The decrease in functional C'2 activity in these sera was found to correlate with a decrease in the amount of a serum globulin which is presumably C'2. Individuals homozygous for the C'2 deficiency lack immunochemically measurable serum C'2. Heterozygous C'2 deficient individuals have 30% to 60% of normal C'2.

Footnotes

This study was supported by United States Public Health Service Grant 5-PO1-AI05877-05.