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Poliovirus Antibody Response in Serum and Nasal Secretions Following Intranasal Inoculation with Inactivated Poliovaccine¹

From the Departments of Pediatrics and Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York

Abstract

Secretory antibody response in nasal secretions has been studied following intranasal inoculation of large doses of inactivated poliovaccine. Secretory A antibody appeared in the nasal secretions as early as 5 days after the first dose of a primary series of three intranasal doses of vaccine, and the antibody activity disappeared by 77 to 100 days. The response to a secondary intranasal inoculation of inactivated vaccine 3 to 4 months later, although shorter-lived, was generally similar to the primary response. There was no evidence of anamnesis. The secretory A response appeared in the absence of any significant serum response. High titers of secretory antibody in nasal secretions seemed to depress nasopharyngeal replication of live attenuated virus administered orally, although no effect on virus replication in the lower alimentary tract was observed.

Footnotes

This study was supported by General Research Support Grants FR-05493 and FR-05400 from the United State Public Health Service, and Research Grant AI-02396 from the National Institute of Allergy and Infectious Diseases.

² Send reprint requests to: Pearay L. Ogra, M.D., Department of Pediatrics, Children's Hospital, 219 Bryant Street, Buffalo, New York, 14222.

³ Recipient of Research Career Award AI-1136 from the National Institute of Allergy and Infectious Diseases. Present address: Department of Pediatrics, School of Medicine, Vanderbilt University, Nashville, Tennessee, 37203.

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