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The Journal of Immunology, 1969, 102: 117-122.
Copyright © 1969 by The American Association of Immunologists, Inc.
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Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus1

Geoffrey Clark, Morris Reichlin2 and Thomas B. Tomasi, Jr.

From the Department of Medicine, State University of New York at Buffalo, Buffalo, New York

Abstract

A tissue antigen reactive with sera from SLE patients has been partially characterized. The antigen is a soluble cytoplasmic component which is present in a variety of human tissues and is distinct from known nuclear antigens. It is an acidic macromolecule which has the electrophoretic mobility of an {alpha}1 globulin and is resistant to most proteolytic enzymes including trypsin, pepsin and chymotrypsin. Antigenicity is destroyed by 0.02 M periodate and by 0.001 M parahydroxy mercuribenzoate. Antibodies to this antigen have been found in 40% of unselected LE sera and were absent from a large number of sera from normal persons and from the sera of patients with other connective tissue disorders.

Footnotes

Supported by United States Public Health Service Research Grants 2-RO1-AM10428 and 2-RO1-AM10419.

2 Career Development Award 5-K3-AM-20-729-02.




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