The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1969, 102, 117 -122
Copyright © 1969 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clark, G.
Right arrow Articles by Tomasi, T. B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Clark, G.
Right arrow Articles by Tomasi, T. B., Jr.

Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus1

Geoffrey Clark, Morris Reichlin2 and Thomas B. Tomasi, Jr.

From the Department of Medicine, State University of New York at Buffalo, Buffalo, New York

Abstract

A tissue antigen reactive with sera from SLE patients has been partially characterized. The antigen is a soluble cytoplasmic component which is present in a variety of human tissues and is distinct from known nuclear antigens. It is an acidic macromolecule which has the electrophoretic mobility of an {alpha}1 globulin and is resistant to most proteolytic enzymes including trypsin, pepsin and chymotrypsin. Antigenicity is destroyed by 0.02 M periodate and by 0.001 M parahydroxy mercuribenzoate. Antibodies to this antigen have been found in 40% of unselected LE sera and were absent from a large number of sera from normal persons and from the sera of patients with other connective tissue disorders.

Footnotes

Supported by United States Public Health Service Research Grants 2-RO1-AM10428 and 2-RO1-AM10419.

2 Career Development Award 5-K3-AM-20-729-02.




This article has been cited by other articles:


Home page
 IOVSHome page
G. Jiang, Y. Ke, D. Sun, H. Li, M. Ihnen, M. M. Jumblatt, G. Foulks, Y. Wang, Y. Bian, H. J. Kaplan, et al.
A New Model of Experimental Autoimmune Keratoconjunctivitis Sicca (KCS) Induced in Lewis Rat by the Autoantigen Klk1b22
Invest. Ophthalmol. Vis. Sci., May 1, 2009; 50(5): 2245 - 2254.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
I Cavazzana, A Ceribelli, M Quinzanini, M Scarsi, P Airo, R Cattaneo, and F Franceschini
Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseases
Lupus, August 1, 2008; 17(8): 727 - 732.
[Abstract] [PDF]

Home page
 LupusHome page
M Jeffries, F Hamadeh, T Aberle, S Glenn, D. Kamen, J. Kelly, M Reichlin, J. Harley, and A. Sawalha
Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective
Lupus, August 1, 2008; 17(8): 739 - 743.
[Abstract] [PDF]

Home page
 LupusHome page
M Jeffries, G Bruner, S Glenn, P Sadanandan, C. Carson, J. Harley, and A. Sawalha
Sulpha allergy in lupus patients: a clinical perspective
Lupus, March 1, 2008; 17(3): 202 - 205.
[Abstract] [PDF]

Home page
 LupusHome page
S. Malik, G.R. Bruner, C. Williams-Weese, L. Feo, R. Hal Scofield, M. Reichlin, J.B. Harley, and A.H. Sawalha
Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients
Lupus, November 1, 2007; 16(11): 863 - 866.
[Abstract] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. Gerosa, R. Cimaz, M. Stramba-Badiale, K. Goulene, E. Meregalli, L. Trespidi, B. Acaia, R. Cattaneo, A. Tincani, M. Motta, et al.
Electrocardiographic abnormalities in infants born from mothers with autoimmune diseases a multicentre prospective study
Rheumatology, August 1, 2007; 46(8): 1285 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
I Cavazzana, F Franceschini, C Vassalini, E Danieli, M Quinzanini, P Airo, and R Cattaneo
Clinical and serological features of 35 patients with anti-Ki autoantibodies
Lupus, October 1, 2005; 14(10): 837 - 841.
[Abstract] [PDF]

Home page
 LupusHome page
F Neri, L Chimini, F Bonomi, E Filippini, M Motta, D Faden, A Lojacono, C B. Rebaioli, M Frassi, E Danieli, et al.
Neuropsychological development of children born to patients with systemic lupus erythematosus
Lupus, October 1, 2004; 13(10): 805 - 811.
[Abstract] [PDF]

Home page
 LupusHome page
F J Lopez-Longo, M Rodriguez-Mahou, M Escalona-Monge, C M Gonzalez, I Monteagudo, and L Carreno
Simultaneous identification of various antinuclear antibodies using an automated multiparameter line immunoassay system
Lupus, August 1, 2003; 12(8): 623 - 629.
[Abstract] [PDF]

Home page
 BloodHome page
R. H. Scofield, G. R. Bruner, J. A. Kelly, J. Kilpatrick, D. Bacino, S. K. Nath, and J. B. Harley
Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13
Blood, February 1, 2003; 101(3): 992 - 997.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
A Brucato, A Doria, M Frassi, G Castellino, F Franceschini, D Faden, M P. Pisoni, L Solerte, M Muscara, A Lojacono, et al.
Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study
Lupus, November 1, 2002; 11(11): 716 - 721.
[Abstract] [PDF]

Home page
 LupusHome page
M Reichlin
ENA: its place in medicine
Lupus, April 1, 2002; 11(4): 201 - 203.
[PDF]

Home page
 Clin. Cancer Res.Home page
J. E. Tomkiel, H. Alansari, N. Tang, J. B. Virgin, X. Yang, P. VandeVord, R. L. Karvonen, J. L. Granda, M. J. Kraut, J. F. Ensley, et al.
Autoimmunity to the Mr 32,000 Subunit of Replication Protein A in Breast Cancer
Clin. Cancer Res., March 1, 2002; 8(3): 752 - 758.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
A N Scofield, B T Kurien, T P Gordon, and R H Scofield
Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjogren's syndrome?
Lupus, August 1, 2001; 10(8): 547 - 553.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
O. D. Schein, M. C. Hochberg, B. Munoz, J. M. Tielsch, K. Bandeen-Roche, T. Provost, G. J. Anhalt, and S. West
Dry Eye and Dry Mouth in the Elderly: A Population-Based Assessment
Arch Intern Med, June 28, 1999; 159(12): 1359 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
L Carreno, F J Lopez-Longo, I Monteagudo, M Rodriguez-Mahou, M Bascones, C M Gonzalez, C Saint-Cyr, and N Lapointe
Immunological and clinical differences between juvenile and adult onset of systemic lupus erythematosus
Lupus, May 1, 1999; 8(4): 287 - 292.
[Abstract] [PDF]

Home page
 JEMHome page
U. S. Deshmukh, J. E. Lewis, F. Gaskin, C. C. Kannapell, S. T. Waters, Y.-h. Lou, K. S.K. Tung, and S. M. Fu
Immune Responses to Ro60 and Its Peptides in Mice. I. The Nature of the Immunogen and Endogenous Autoantigen Determine the Specificities of the Induced Autoantibodies
J. Exp. Med., February 1, 1999; 189(3): 531 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. He and Y.-L. Lin
In Vitro Stimulation of C1s Proteolytic Activities by C1s-Presenting Autoantibodies from Patients with Systemic Lupus Erythematosus
J. Immunol., May 1, 1998; 160(9): 4641 - 4647.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
D. A. Ruddy, G. S. Kronmal, V. K. Lee, G. A. Mintier, L. Quintana, R. Domingo Jr., N. C. Meyer, A. Irrinki, E. E. McClelland, A. Fullan, et al.
A 1.1-Mb Transcript Map of the Hereditary Hemochromatosis Locus
Genome Res., May 1, 1997; 7(5): 441 - 456.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
F. Lopez-Longo, I. Monteagudo, C. Gonzalez, R. Grau, and L. Carreno
Systemic lupus erythematosus: clinical expression and anti-Ro/SS--A response in patients with and without lesions of subacute cutaneous lupus erythematosus
Lupus, January 1, 1997; 6(1): 32 - 39.
[Abstract] [PDF]

Home page
 LupusHome page
N. Rowell
Some historical aspects of skin disease in lupus erythematosus
Lupus, January 1, 1997; 6(2): 76 - 83.
[PDF]

Home page
 LupusHome page
D. McCauliffe
Cutaneous diseases in adults associated with Anti-Ro/SS-A autoantibody production
Lupus, January 1, 1997; 6(2): 158 - 166.
[PDF]

Home page
 LupusHome page
R. Scofield, B. Kurien, and M. Reichlin
Immunologically restricted and inhibitory anti-Ro/SSA in monozygotic twins
Lupus, January 1, 1997; 6(4): 395 - 398.
[Abstract] [PDF]

Home page
 LupusHome page
T. Kawashima, E. G. Zappi, T.-S. Lieu, and R. D Sontheimer
Impact of Ultraviolet Irradiation on Expression of SSA/Ro Autoantigenic Polypeptides in Transformed Human Epidermal Keratinocytes
Lupus, December 1, 1994; 3(6): 493 - 500.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
L. A. Lee, C. M. Roberts, M. B. Frank, V. R. McCubbin, and M. Reichlin
The Autoantibody Response to Ro/SSA in Cutaneous Lupus Erythematosus
Arch Dermatol, October 1, 1994; 130(10): 1262 - 1268.
[Abstract] [PDF]

Home page
 LupusHome page
L. A. Lee, M. Reichlin, S. Z. Ruyle, and W. L. Weston
Neonatal Lupus Liver Disease
Lupus, October 1, 1993; 2(5): 333 - 338.
[Abstract] [PDF]

Home page
 LupusHome page
J.F. Meilof, Lm.E. Frohn-Mulder, P.A. Steward, A. Szatmari, J. Hess, C.H.A. Veldhoven, R.J.T. Smeenk, and A.J.G. Swaak
Maternal Autoantibodies and Congenital Heart Block: No Evidence for the Existence of a Unique Heart Block-associated Anti-Ro/SS-A Autoantibody Profile
Lupus, August 1, 1993; 2(4): 239 - 246.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
R Peek, G. Pruijn, A. van der Kemp, and W. van Venrooij
Subcellular distribution of Ro ribonucleoprotein complexes and their constituents
J. Cell Sci., January 11, 1993; 106(3): 929 - 935.
[Abstract] [PDF]

Home page
 LupusHome page
J.F. Meilof, I.M.E. Frohn-Mulder, P.A. Steward, A. Szatmari, J. Hess, C.H.A. Veldhoven, R.J.T. Smeenk, and A.J.G. Swaak
Maternal Autoantibodies and Congenital Heart Block: No Evidence for the Existence of a Unique Heart Block-associated Anti-Ro/SS-A Autoantibody Profile
Lupus, January 1, 1993; 2(1_suppl): 239 - 246.
[Abstract] [PDF]

Home page
 LupusHome page
Pereira, N. H. Yoshinari, R. M. De Oliveira, and W. Cossermelli
Antiganglioside Antibodies in Patients with Neuropsychiatric Systemic Lupus Erythematosus
Lupus, May 1, 1992; 1(3): 175 - 179.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
K. LASSOUED, M.-N. GUILLY, F. DANON, C. ANDRE, D. DHUMEAUX, J.-P. CLAUVEL, J.-C. BROUET, M. SELIGMANN, and J.-C. COURVALIN
Antinuclear Autoantibodies Specific for Lamins: Characterization and Clinical Significance
Ann Intern Med, June 1, 1988; 108(6): 829 - 833.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
E. Alexander and T. T. Provost
Sjogren's Syndrome: Association of Cutaneous Vasculitis With Central Nervous System Disease
Arch Dermatol, June 1, 1987; 123(6): 801 - 810.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
E. A. Lerner and M. R. Lerner
Whither the ANA?
Arch Dermatol, March 1, 1987; 123(3): 358 - 362.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
E. L. ALEXANDER, K. MALINOW, J. E. LEJEWSKI, M. S. JERDAN, T. T. PROVOST, and G. E. ALEXANDER
Primary Sjogren's Syndrome with Central Nervous System Disease Mimicking Multiple Sclerosis
Ann Intern Med, March 1, 1986; 104(3): 323 - 330.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
R. D. Sontheimer
Immunobiological Significance of the Ro/SSA Antigen-Antibody System
Arch Dermatol, March 1, 1985; 121(3): 327 - 330.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
D. J. Wermuth, W. D. Geoghegan, and R. E. Jordon
Anti-Ro/SSA Antibodies: Association With a Particulate (Large Speckledlike Thread) Immunofluorescent Nuclear Staining Pattern
Arch Dermatol, March 1, 1985; 121(3): 335 - 338.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
J. D. REVEILLE, R. W. WILSON, T. T. PROVOST, W. B. BIAS, and F. C. ARNETT
Primary Sjogren's Syndrome and Other Autoimmune Diseases in Families: Prevalence and lmmunogenetic Studies in Six Kindreds
Ann Intern Med, December 1, 1984; 101(6): 748 - 756.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
A. T. Lane and R. M. Watson
Neonatal Lupus Erythematosus
Arch Pediatr Adolesc Med, July 1, 1984; 138(7): 663 - 666.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
H. L. Wechsler
Lupus Erythematosus: A Clinician's Coign of Vantage
Arch Dermatol, November 1, 1983; 119(11): 877 - 882.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
T. T. Provost
Commentary: Neonatal Lupus Erythematosus
Arch Dermatol, July 1, 1983; 119(7): 619 - 622.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
R. D. SONTHEIMER, P. J. MADDISON, M. REICHLIN, R. E. JORDON, P. STASTNY, and J. N. GILLIAM
Serologic and HLA Associations in Subacute Cutaneous Lupus Erythematosus, a Clinical Subset of Lupus Erythematosus
Ann Intern Med, November 1, 1982; 97(5): 664 - 671.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
S. Miyagawa, W. Kitamura, J. Yoshioka, and K. Sakamoto
Placental Transfer of Anticytoplasmic Antibodies in Annular Erythema of Newborns
Arch Dermatol, September 1, 1981; 117(9): 569 - 572.
[Abstract] [PDF]

Home page
 ScienceHome page
M. Lerner, J. Boyle, J. Hardin, and J. Steitz
Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus
Science, January 23, 1981; 211(4480): 400 - 402.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
J. L. Millns, F. C. McDuffie, S. A. Muller, and R. E. Jordon
Development of Photosensitivity and an SLE-like Syndrome in a Patient With Psoriasis
Arch Dermatol, August 1, 1978; 114(8): 1177 - 1181.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
V. Kumar, W. L. Binder, E. Schotland, E. H. Beutner, and T. P. Chorzelski
Coexistence of Bullous Pemphigoid and Systemic Lupus Erythematosus
Arch Dermatol, August 1, 1978; 114(8): 1187 - 1190.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-C. Labbe, J. Burgess, L. A. Rokeach, and S. Hekimi
ROP-1, an RNA quality-control pathway component, affects Caenorhabditis elegans dauer formation
PNAS, November 21, 2000; 97(24): 13233 - 13238.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1969 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1969 by The American Association of Immunologists, Inc. All rights reserved.