The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1968, 101: 1192-1198.
Copyright © 1968 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tevethia, S. S.
Right arrow Articles by Enders, J. F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Tevethia, S. S.
Right arrow Articles by Enders, J. F.

Lack of Relationship between Virus-Specific Surface and Transplantation Antigens in Hamster Cells Transformed by Simian Papovavirus SV401

Satvir S. Tevethia2, George Th. Diamandopoulos, Fred Rapp3 and John F. Enders

Department of Virclogy and Epidemiology, Baylor University College of Medicine, Houston, Texas; and Research Division of Infectious Diseases, The Children's Hospital Medical Center, and the Departments of Pathology, and Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts

Abstract

The relationship between SV40 surface (S) and transplantation antigens in hamster cells transformed by SV40 was investigated by carrying out transplantation rejection tests in weanling hamsters and by ability of x-irradiated cells to prevent viral tumorigenesis in newborn animals. Only the cells which contained detectable levels of virus-specific tumor (T) and S antigens were found to contain detectable levels of transplantation antigens. The cells which had only the S antigen and cells which synthesized neither S nor T antigens did not contain detectable levels of transplantation antigens. These results strongly suggest that the S antigen detected in vitro by the immunofluorescence test in cells not synthesizing the T antigen is not identical with the SV40 transplantation antigen involved in the rejection or protection phenomena.

Footnotes

This study was supported in part by Research Grant AI-01992 from the National Institute of Allergy and Infectious Diseases, and CA-04600 and CA-08731 from the National Cancer Institute, National Institutes of Health.

2 Recipient of Research Career Development Award No. 1-K3-CA38,614 from the National Cancer Institute, National Institutes of Health.

3 American Cancer Society Professor of Virology.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1968 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1968 by The American Association of Immunologists, Inc. All rights reserved.