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Experimental Inclusion Conjunctivitis in Man

IV. The Nature of the Antibody Response¹

Department of Microbiology, University of California Medical Center, San Francisco, California 94122

Abstract

The serum antibody response of volunteers experimentally infected with either of two inclusion conjunctivitis strains (IC Cal 3 or IC Cal 8) was studied by the complement fixation (C'F) and indirect fluorescent antibody (IFA) methods. In most sera both the C'F and IFA titers increased in parallel and reached a maximum level 4 to 6 weeks after infection. The C'F- and IFA-reactive antibodies were confined primarily to the IgG class of immunoglobulin. Low levels of IFA-reactive antibodies were detectable in some IgA fractions, but no antibody activity was detected by either the C'F or the IFA method in the IgM fractions of sera as early as 13 days and as late as 2 years after infection.

Footnotes

This study was supported by grants from the National Institutes of Health (NB 00604 and 5 T01 AI00299) and the Burroughs Wellcome Fund.

² Submitted in partial fulfillment of the requirements for the Ph.D. degree at the University of California, San Francisco.