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The Effect of Passive Antibody on Protein Synthesis in Lymph Node Cells of Immunized Rats¹

From the Irvington House Institute and Department of Medicine, New York University School of Medicine New York 10016

Abstract

The incorporation of leucine into popliteal lymph node cells was studied in immunized rats some of which received passive antibody 2 days after antigen. In rats receiving antigen alone, there was a phase of increased incorporation into the cytoplasm beginning on day 4, which corresponded to the phase of rapid antibody synthesis. The administration of passive antibody prevented this phase but transiently stimulated increased incorporation of leucine, which reached a peak on day 4. It was suggested that this transient phase represents stimulation of lymphocytes by antigen-antibody complexes.

Footnotes

This work was done under the sponsorship of the Commission on Immunization of the Armed Forces Epidemiological Board, and was supported in part by the U.S. Army Medical Research and Development Command, Department of the Army, under Research Contract DA-49-193-MD-2043, and in part by United States Public Health Service Grant AI-08034 and by the Health Research Council of the City of New York Grant U-1647.

² Present address: Union Carbide Research Institute, P.O. Box 278, Tarrytown, New York.