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Transfer with RNA Extracts of the Cell Migration Inhibition Correlate of Delayed Hypersensitivity in the Guinea Pig^1,2,

From the Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois

Abstract

When guinea pig nonsensitive peritoneal exudate cells were incubated with RNA extracts obtained from the lymph nodes and spleens of guinea pigs sensitive to PPD or coccidioidin, the migration of these cells from capillary tubes was specifically inhibited by the antigen to which the RNA donor was sensitive. Neither the antigen alone nor RNA extracts from unimmunized guinea pigs were able to convert these cells to a state of sensitivity.

Footnotes

¹ This paper was presented in part as an abstract at the 52nd Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, April 15–20, 1968.

² This work was supported by Research Grant GB 5536 from the National Science Foundation and by Training Grant PHS 1 T01 AI00335 and Research Grant PHS AI07043 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service.

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