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Communications

Rapid Induction of Experimental Allergic Thyroiditis in Rats Sensitized to Thyroid-Adjuvant and Pertussis Vaccine

From the Samuel J. Sackett Research Laboratories and the Infectious Diseases-Hypersensitivity Section, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois

Abstract

The remarkable adjuvant properties of pertussis vaccine in augmenting and intensifying responses to nervous tissue-adjuvant and in accelerating the induction of EAE in mice (5) and rats (3, 6) are well known. During our studies, Levine and Wenk (7) described accelerated production of adrenalitis in rats and Hargio et al. (8) reported enhanced induction of aspermatogenesis in mice sensitized to adrenal gland and testes combined with pertussis vaccine, respectively. Our observations (Table I) indicate that pertussis vaccine also has a dramatic influence on the production of another experimental auto-immune disease, EAT, in the rat. Pertussis vaccine offers not only a specific and practical means for rapid induction of hyperacute experimental autoimmune diseases, but also a promising means for further probing the pathogenesis of auto-allergic sensitization and tissue injury.

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