HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Davis, W. C. Articles by Fudenberg, H. H. Search for Related Content PubMed Articles by Davis, W. C. Articles by Fudenberg, H. H.

Communications

A Defect in Circulating Mononuclear Phagocytes in Chronic Granulomatous Disease of Childhood¹

From the Department of Medicine, University of California School of Medicine, San Francisco, California 94122

Abstract

Defective intracellular killing of bacteria by purified circulating mononuclear phagocytes is demonstrated in chronic granulomatous disease of childhood. The relationship of this defect to the characteristic histopathologic finding of pigmentladen macrophages is considered. CGD is a genetic disease which is manifested by impaired bactericidal capacity of at least two circulating cell types, polymorphonuclear neutrophils and mononuclear phagocytes.

Footnotes

This investigation was supported by Training Grant HE-05677 and Research Grant HE-05997 from the United States Public Health Service, Contract NONR-3656 from the Office of Naval Research, a grant from Merck, Sharp and Dohme, and funds from the Committee on Research Allocation and Evaluation of the University of California (San Francisco) Medical Center.

² Postdoctoral Trainee in Hematology.

³ Recipient of a Max Kade Foundation Fellowship.

⁴ Requests for reprints should be addressed to H. Hugh Fudenberg, M.D., Professor of Medicine, Section of Hematology & Immunology, University of California Medical Center, San Francisco, California 94122.

This article has been cited by other articles:

				S. D. Douglas Monocytes/Macrophages in Diagnosis and Immunopathogenesis Clin. Vaccine Immunol., May 1, 1999; 6(3): 283 - 285. [Full Text] [PDF]