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Abstracts of Papers Presented at the Third International Complement Workshop, Harvard Medical School, Boston, Massachusetts, June 3–5, 1968

Metabolism of Purified Radio-Labeled C'4 and C'4i in Man

Hospitals and Department of Medicine, Harvard Medical School, Boston, Mass., and Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, Calif.

Abstract

Radioiodinated C'4 (_1E globulin) was given intravenously to 11 renal allograft recipients and one anephric patient prior to transplantation. The catabolic and synthetic rates were determined by analysis of plasma, urine and stool radioactivities over the course of 6 to 9 days. The purpose of this study was to define the metabolic behavior of normal (ranging from 27 to 100% of specific functional activity of native C'4) and inactivated C'4 and to determine the method of analysis appropriate for such investigations. In patients with normal renal function, there was good agreement between catabolic rates derived from a multiexponential analysis of the plasma protein-bound radioactivity curve and the urinary excretion rate of free iodide. Impairment of renal function per se did not influence catabolic rates. In patients without evidence of rejection at the time of study, the catabolic rates (% of plasma pool/hour) ranged from 1.2 to 2.6% (mean, 1.9 ± 0.6%).