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The Journal of Immunology, 1968, 101: 788-790.
Copyright © 1968 by The American Association of Immunologists, Inc.
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The Biologic Role of Host Antigens in Newcastle Disease Virus

V. M. Zhdanov and G.-K. S. Chepulis

D. I. Ivanovsky Institute of Virology, Moscow, USSR

Abstract

An immunologic phenomenon is described: induction of susceptibility of mice to infection by chicken embryo-adapted NDV in animals rendered "tolerant" to chicken embryo antigens. "Tolerant" mice developed pulmonary lesions and viremia after intranasal inoculation of NDV and the virus could subsequently be maintained in mice by direct passage. Susceptibility to the virus was not induced in animals injected as newborns with heterologous antigens.






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