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The Production of Thyroid Autoantibodies in Mice¹

From the Department of Microbiology, State University of New York at Buffalo, School of Medicine, Buffalo, New York

Abstract

Circulating thyroid autoantibodies have been produced in mice by the injection of either homologous or heterologous (rat and rabbit) thyroid extract incorporated in complete Freund adjuvant. Rat thyroid extract injected without adjuvant also was capable of eliciting antibodies directed against both rat and mouse thyroid extract. Even though normal animals did not respond to aqueous mouse thyroid extract (MTE), animals previously sensitized with the same antigen in complete Freund adjuvant, or syngeneic recipients of lymphoid cells from sensitized donors, readily responded to a similar injection. These results imply the production of a new population of responsive cells following initial stimulation. Histologic examination of thyroid glands from inbred mice sensitized under a wide variety of conditions revealed no pathologic changes despite the presence over a long period of time of circulating antibody demonstrated by tanned cell hemagglutination and passive cutaneous anaphylaxis.

Footnotes

This work was supported by National Institutes of Health Research Grants CA-05203 and CA-02357 from the United States Public Health Service.

² Taken in part from a Ph.D. dissertation presented by Frank J. Twarog to the Faculty of the Graduate School of the State University of New York at Buffalo. The senior author was supported by National Institutes of Health Training Grant 5-T1A1130-07 from the United States Public Health Service.

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