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Differences in the Amino Acid Compositions of Allogeneic Guinea Pig Transplantation Antigens

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Amino acid analyses were performed on relatively homogeneous guinea pig transplantation antigens, which had been liberated by exposure to sound and purified by gel filtration and by discontinuous electrophoresis on polyacrylamide gel. Comparison of the amino acid compositions of the antigens extracted from two histoincompatible lines of guinea pigs revealed significant differences in their content of serine, alanine, leucine, isoleucine and valine. These data suggest that transplantation antigens have allotypic specificities related to protein structure.

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				B. D. Kahan and R. A. Reisfeld Transplantation Antigens Science, May 2, 1969; 164(3879): 514 - 521. [PDF]