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Availability of Isoantigens to Circulating Antibodies¹

From the Department of Biochemistry Research, Roswell Park Memorial Institute, Buffalo, New York

Abstract

Iodinated and purified C57BL/6 anti-DBA/2 isoantibodies have been shown to exhibit in vivo localization in organs of DBA/2 mice when injected. Lung, spleen and liver fixed large proportions of the injected antibodies while kidney, thymus, lymph nodes, and heart did not fix large amounts of isoantibodies.

Only minute amounts of isoantibodies were fixed in the brain, but the localization was highly specific. There was essentially no localization of normal globulin in the brain.

No localization could be detected in organs of C57BL/6 mice which served as isoantibody donors. Some cross-localization was observed in the tissues of other inbred strains, depending on their genetic relation to the DBA/2 mice.

The degree of in vivo localization of isoantibodies does not represent the amount of the corresponding isoantigens in a certain organ, but depends mostly on the availability of these antigens to localizing antibodies.

Footnotes

This work was supported in part by Contract AT-(30-1)-2651 from the Atomic Energy Commission.