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The Journal of Immunology, 1968, 101: 210-216.
Copyright © 1968 by The American Association of Immunologists, Inc.
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Immunodiffusion Reactions with Rubella Antigens1

Nathalie J. Schmidt and Bohumil Styk2

From the Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley, California

Abstract

Immune precipitates were demonstrable in gel double diffusion tests with the viral and soluble antigens of rubella using agarose and a "chamber" technique employing a plastic matrix over a thin layer of gel. Soluble antigens gave heavier lines of precipitate than did viral antigens, possibly due to better diffusion of the smaller antigen. The immunologic relationship between viral (large-particle) and soluble (small-particle) antigens which was suggested by previous studies using complement fixation, hemagglutination inhibition and neutralization tests was confirmed by the results of immunodiffusion studies. Reactions of immunologic identity were obtained between viral and soluble antigens and between antibodies produced to either of these antigens.

Footnotes

The work on which this report is based was supported by Grant AI-01475 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service.

2 Permanent address: Institute of Virology, Czechoslovak Academy of Sciences, Bratislava 9, Czechoslovakia. The author was enabled to conduct research in the United States as reported in this paper through his participation in the exchange program supported by the Czechoslovak Academy of Sciences, and the National Academy of Sciences of the United States of America.






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