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The Journal of Immunology, 1968, 101: 62-67.
Copyright © 1968 by The American Association of Immunologists, Inc.

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Antibody Response in Humans to Deoxycholate-Treated Influenza Virus Vaccine

A. E. Duxbury, A. W. Hampson and J. G. M. Sievers

From the Commonwealth Serum Laboratories, Parkville, Australia

Abstract

A subunit influenza vaccine, prepared by deoxycholate treatment of aqueous influenza virus vaccine concentrates, has been shown to be of comparable antigenicity to the unmodified vaccine when injected into young adult males.

When used in high dosage the vaccine induced high antibody levels and caused no undesirable systemic reactions.




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M. R. Hilleman
Toward Control of Viral Infections of Man
Science, May 2, 1969; 164(3879): 506 - 514.
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