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Immunologic Studies of a Partially Purified Sheep Erythropoietin¹

From the Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania

Abstract

One-third of immune sera from rabbits immunized with a partially-purified sheep ESF were able to neutralize completely or partially the biologic activity of a given amount of sheep ESF. Stronger ESF-neutralizing immune sera were also able to suppress normal mouse erythropoiesis and to neutralize heterologous anemic sera. Weaker ESF-neutralizing sera did not significantly decrease normal mouse erythropoiesis and did not regularly neutralize heterologous anemic sera. Therefore a relative species-specificity of immune serum to sheep ESF is postulated. The similarity to insulin and growth hormone, two protein hormones capable of giving rise to antibodies in species in which they are biologically active, is stressed and possible causes of the antigenicity of sheep ESF in rabbits are briefly discussed.

Footnotes

This investigation was supported by United States Public Health Service Grants H4612 and 6374 and Medical Research Council of Canada Grant MA2360.

² Research Associate in Medicine, Jefferson Medical College and Assistant Member, Cardeza Foundation. Present address: Hôpital de l'Enfant-Jésus, Québec City, Canada.

³ Cardeza Research Professor in Medicine, Jefferson Medical College, and Director, Cardeza Foundation for Hematologic Research, Philadelphia, Pennsylvania.