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Human Serum Interactions with Candida Albicans¹

From the Department of Pediatrics, University of Minnesota College of Medical Sciences, Minneapolis, Minnesota

Abstract

Clumping of Candida albicans occurred when the organisms were incubated in normal human serum. This clumping of yeast and mycelia apparently accounts for the decrease in colony-forming units previously described. Homogenization of serum after incubation showed that clumping did not bring about organism death. Clumping of C. albicans did not occur in sera from three patients with chronic mucocutaneous candidiasis and furthermore these sera inhibited clumping in normal sera. The inhibitor of clumping present in the sera of patients with chronic mucocutaneous candidiasis has been identified as specific IgG C. albicans antibody.

Footnotes

Presented in part at the Annual Meeting of the Federation of American Societies for Experimental Biology, Chicago, April 16 to 21, 1967. This work was supported by grants from the Minnesota Division of the American Cancer Society, University of Minnesota Graduate School, United States Public Health Service (AI 07726, AI 06931, HE 06314), and Institutional Cancer Grant IN13 H, and conducted, in part, under the sponsorship of the Commission on Streptococcal and Staphylococcal Diseases, of the Armed Forces Epidemiology Board and was supported, in part, by the United States Army Medical Research and Development Command, Department of the Army, under research contract DA-49-193-MD-971.

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