HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Granger, G. A. Articles by Kolb, W. P. Search for Related Content PubMed Articles by Granger, G. A. Articles by Kolb, W. P.

Ylmphocyte in Vitro Cytotoxicity: Mechanisms of Immune and Non-Immune Small Lymphocyte Mediated Target L Cell Destruction

From the Division of Biological Science, Department of Molecular and Cell Biology, University of California, Irvine, California

Abstract

Mutual in vitro cell destruction resulted when nonimmune or immune mouse or rat small lymphocytes were attached to genetically dissimilar target cells with phytohemagglutinin or xenogeneic antibody. The ability to induce this reaction resided only with viable cells of lymphoid origin. The step(s) leading to aggressor-target cell destruction observed in these studies is suggested by the following sequence: a) attachment of the aggressor cell to the target cell, b) membrane site(s) interaction between the lymphocyte and target cell which serves as a recognition step and if the target cell is not recognized as "self," d) a "triggering" of aggressor lymphocyte activity which results in enlargement of the lymphocyte and release of a soluble toxic factor termed "lymphocyte cytotoxic factor" (LCF). LCF may be the agent responsible for the death of both cells.

Footnotes

Supported by Grant AI 07839-01 from the National Institutes of Health.

² Predoctoral fellow supported by Grant FIGM-37, 389-01 from the National Institutes of Health.

This article has been cited by other articles:

				I. D. Bernstein, D. E. Thor, B. Zbar, and H. J. Rapp Tumor hnmunity: Tumor Suppression in vivo Initiated by Soluble Products of Specifically Stimulated Lymphocytes Science, May 14, 1971; 172(3984): 729 - 731. [Abstract] [PDF]

				D. N. Buell and J. L. Fahey Limited Periods of Gene Expression in Immunoglobulin-Synthesizing Cells Science, June 27, 1969; 164(3887): 1524 - 1525. [Abstract] [PDF]