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Antimuscle Factor and Antinuclear Factor in Patients with Myasthenia Gravis

I. Heavy Chain Determinants

From the Medical Neurology Branch, National Institute of Neurological Diseases and Blindness, and the Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

A three-layer indirect immunofluorescence technique was used to study the classes of immunoglobulins responsible for AMF and ANF in sera from patients with myasthenia gravis. AMF was found in IgG but not in IgA or IgM. In contrast ANF was detected in all three major classes. In individual sera this reactivity occurred in one, two or three immunoglobulin classes. Evidence is presented that ANF and AMF, although frequently found in the same serum, behave as separate serologic entities.

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