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Vaccination Response in Rabbits Related to Quantity of Vaccinia Virus Particles and Passage Level¹

From the Biophysics Laboratory, Bacteriology Department, School of Medicine, University of North Carolina, Chapel Hill, North Carolina

Abstract

The antigenicity and immunizing potential of early and late L cell passage vaccinia virus were compared. Early passage virus produced a skin lesion in rabbits if as few as 200 VP were injected. Late passage virus produced no necrotic lesion in concentrations as high as 10⁹ VP. Both early and late passage virus immunization gave skin immunity to challenge by early passage virus. Early passage virus stimulated high titers of neutralizing antibody; late passage virus produced lower antibody titers.

Footnotes

This investigation was supported by Grant GM-05177 from the National Institutes of Health.

² Present address: Laboratory of Virology and Rickettsiology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland.

³ Present address: Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia.