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Induced Localization of Allergic Adrenalitis and Encephalomyelitis at Sites of Thermal Injury¹

From the New York Medical College Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, New York, New York

Abstract

Experimental allergic encephalomyelitis (EAE) was produced by active immunization with neural antigen and by passive transfer with living lymphoid cells. The lesions of both types of EAE localized around areas of brain damaged by heat, as has been reported in the past for a number of other nonspecific brain injuries. Allergic adrenalitis was also produced by active immunization and by passive transfer. Induced localization of both forms of adrenalitis at sites of thermal injury was demonstrated for the first time. Heat lesions 5 days or older were effective. Induced localization occurred within 24 hr and was organ specific. However, 1-day-old heat lesions of brain and 1- or 2-day-old heat lesions of adrenal were not conducive to localization of the corresponding autoimmune disease. The ineffectiveness of these very recent heat lesions was not related to a systemic stress reaction. The longer duration of the period of ineffectiveness in the adrenal was paralleled by a slower evolution of the healing process in the adrenal as compared to the brain, and both may be related to some local tissue characteristic specific for the adrenal.

Footnotes

This investigation was supported by Grant NB 05727 from the National Institute of Neurological Diseases and Blindness, United States Public Health Service.

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