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An In Vitro Assay for Encephalitogenic Components of Central Nervous Tissue¹

From the Biochemistry Research Department, Lederle Laboratories, Division of the American Cyanamid Company, Pearl River, New York

Abstract

It has been demonstrated that an encephalitogenic purified basic protein fraction from bovine spinal cord inhibited the migration in tissue culture of peritoneal exudate cells from sensitized guinea pigs and rats. A technique based on this observation has been developed for an assay of such encephalitogenic fractions. Where practical considerations required pooling, cells pooled from imbred animals were superior because cells pooled from random-bred animals appeared to give variable mutual inhibition.

Footnotes

¹ Presented in part at the 51st Annual Meeting of the Federation of American Societies for Experimental Biology, Chicago, Illinois, April 19, 1967, Abstract no. 1536.

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