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Immunologic Incompetence of Mouse Perinatal Liver Hematopoietic Cells against Transplantation Antigens^1,2,

From the May and Sigmund Winter Research Laboratory, Mount Sinai Hospital, and the Department of Medicine and Surgery, Marquette Medical School, Inc., Milwaukee, Wisconsin³

Abstract

Liver hematopoietic cells were collected from fetal and neonatal C57BL/6 mice at eight equidistant points in time beginning on the 13th day of fetal life and ending on the 7th day after birth. Aliquots of these cells were administered intraperitoneally to B6D2F₁ mice. The host mice were studied by means of the Simonsen graft-vs.-host spleen weight-gain assay to determine at what stage of fetal or neonatal life mouse liver hematopoietic cells first acquire immunologic competence against transplantation antigens. None of the mouse liver hematopoietic cells from fetal or neonatal parental strain mice demonstrated immunologic reactivity against transplantation antigens in their F₁ hybrids with the doses employed and as measured by this assay system.

Footnotes

¹ Presented at the Tenth Anniversary Bone Marrow Conference, November 17, 18, 1967, Oak Ridge, Tennessee.

² Research supported by grants from the American Cancer Society (Milwaukee Division) and the Board of Directors, Mount Sinai Hospital.

³ Mailing address: May and Sigmund Winter Research Laboratory, Mount Sinai Hospital, 948 North Twelfth Street, Milwaukee, Wisconsin 53233.

This article has been cited by other articles:

				M. M. Bortin and E. C. Saltzstein Graft versus Host Inhibition: Fetal Liver and Thymus Cells to Minimize Secondary Disease Science, April 18, 1969; 164(3877): 316 - 318. [Abstract] [PDF]