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The Journal of Immunology, 1968, 100: 974-978.
Copyright © 1968 by The American Association of Immunologists, Inc.
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Role of the Thymus in Tolerance

VI. Tolerance to Bovine {gamma}-Globulin in Rats Given a Low Dose of Irradiation and Injection of Nonaggregated or Aggregated Antigen Into the Shielded Thymus1

Atsushi Horiuchi2 and Byron H. Waksman

From the Department of Microbiology, Yale University, New Haven, Connecticut

Abstract

Adult rats received 467 r of whole body irradiation with shielding of the thymus and, immediately after, intrathymic or intravenous injection of centrifuged "soluble" or heat-aggregated B{gamma}G. Following challenge with B{gamma}G in complete adjuvant 3 weeks later, the formation of hemagglutinating and precipitating antibody and the development of Arthus and delayed skin reactivity were specifically inhibited, the effect being greater with soluble than aggregated antigen and much greater with intrathymic than intravenous antigen. Delayed reactivity was only partly inhibited by doses of antigen which completely suppressed other responses. Challenge at 10 weeks showed that specific inhibition was present but much diminished.

Footnotes

This work was supported by Grants AI-06112 and AI-06455 of the National Institutes of Health.

2 On leave of absence from the First Department of Internal Medicine, Nihon University School of Medicine, Tokyo.




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