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Studies of the Proteins of Lacrimal Secretions¹

From the Department of Medicine of the State University of New York, Downstate Medical Center and the Kings County Hospital Center, Brooklyn, New York and the Summer Research Institute of the Will Rogers Hospital, Saranac Lake, New York

Abstract

The major immunoglobulin of tears is IgA globulin, which is recovered in the external volume when subjected to Sephadex G 200 gel filtration. This protein contains "transport" or "secretory" piece as does the IgA globulin of other secretions.

Another protein in tears, the anodal tear protein, is not related to albumin but is electrophoretically a "prealbumin." It has gel filtration characteristics consistent with a molecular weight intermediate between that of serum albumin and of lysozyme, and has not been identified in serum, spinal fluid, saliva or urine.

The protein content of tears shows an inverse relationship to the volume of lacrimal fluid obtained during a collection period of less than 5 min.

Footnotes

This study was supported by research Grant 1 RO1 AI0791-01 from the National Institutes of Health and a grant from the American Thoracic Society.

² Career Scientist, Health Research Council of the City of New York under contract I-315.

³ Work done during Research Fellowship at the Summer Research Institute of the Will Rogers Hospital, Saranac Lake, New York and during senior year at Downstate Medical Center.