HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vaz, N. M. Articles by Ovary, Z. Search for Related Content PubMed Articles by Vaz, N. M. Articles by Ovary, Z.

Passive Anaphylaxis in Mice with G Antibodies

III. Release of Histamine from Mast Cells by Homologous Antibodies¹

From the Department of Pathology, New York, University Medical College, New York, New York

Abstract

Anaphylactic release of histamine from mouse mast cells passively sensitized by purified homologous anti-hapten antibodies was demonstrated. The reaction was critically dependent on the Ag-Ab proportions used for sensitization and challenge and could be provoked by addition of freshly prepared Ag-Ab complexes. No fixation of the antibodies to the cells prior to the Ag-Ab reactions could be demonstrated. The release of histamine was complete 2 min after challenge.

Footnotes

Supported by National Institutes of Health Grant AI-03075-08, American Cancer Society Grant No. E-432, and by the Health Research Council, City of New York under Contract I-140.

² Travel fellowship of the Conselho National de Pesquisas, Brazil. Present address: Division of Physiology, Instituto "Oswaldo Cruz," Rio de Janeiro, Brazil.

³ Health Research Council Career Scientist of the City of New York.