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Mediation of Delayed Hypersensitivity by Peripheral Blood Lymphocytes in Vitro and by Their Products in Vivo and in Vitro, Morphology of in Vitro Lymphocyte-Macrophage Interaction^1,2,

From the Immunology and Connective Tissue Division, Department of Medicine, St. Vincent's Hospital Medical Center, New York, New York

Abstract

Peripheral blood lymphocytes from tuberculin hypersensitive guinea pigs and mediating material that these cells produced in the presence of specific antigen altered the activity (migratory potential) of normal macrophages. The mediating material produced by such peripheral lymphocytes caused enhanced tuberculin skin reactions. Its in vitro and in vivo influence on delayed hypersensitivity was inactivated by storage at 4°C and -20°C. Unique associations of lymphocytes and macrophages regularly appeared in cultures of sensitive peritoneal exudate cells, as well as in cultures of mixtures of sensitive peripheral blood lymphocytes with normal peritoneal exudate cells, when specific antigen was in the medium.

Footnotes

¹ Presented in part at the Annual Meeting of the American Society for Cell Biology, November 1967, Denver, Colorado.

² Supported by grants from the New York Tuberculosis and Health Association and the Commonwealth Foundation.

³ Present address: National Institute for Medical Research, Mill Hill, London, N.W. 7.