HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Matangkasombut, P. Articles by Seastone, C. V. Search for Related Content PubMed Articles by Matangkasombut, P. Articles by Seastone, C. V.

Sequence of Events in Mice Early in Immunologic Paralysis by Pneumococcal Polysaccharide¹

From the Department of Medical Microbiology, University of Wisconsin Medical School, Madison, Wisconsin

Abstract

1. By removing the spleens from stimulated mice at intervals and transferring them to -irradiated recipients, it was possible to follow the kinetics of the response to immunizing and paralyzing doses of type I pneumococcal polysaccharide (SI).

2. A linear relationship was established between the degree of adoptive immunity and the logarithm of the number of primed cells transferred.

3. Transient appearance of primed cells was demonstrated in mice developing immunologic paralysis; these cells could no longer be demonstrated 5 days after antigenic stimulation. Cell proliferation appeared to be required.

4. A transient response to a very small immunizing dose similar to that following a paralyzing dose was demonstrated; unresponsiveness was not produced by this amount of SI.

5. Immune suppression was demonstrated when mitomycin C was given prior to the administration of sheep red blood cells or SI.

Footnotes

¹ These studies are part of a dissertation to be submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy at the University of Wisconsin.

² Recipient of a Royal Thai Government Scholarship for faculty development for the Faculty of Medical Sciences, Bangkok, Thailand.

This article has been cited by other articles:

				J. M. Chiller, G. S. Habicht, and W. O. Weigle Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells Science, February 26, 1971; 171(3973): 813 - 815. [Abstract] [PDF]