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Complementarity of Heavy and Light Chains from Antibodies of the Same Specificity Derived from Different Rabbits¹

From the Department of Microbiology, University of Illinois College of Medicine, Chicago, Illinois

Abstract

The specific activity of heavy chains derived from anti-DNP antibody of an individual rabbit was in general enhanced upon combination with light chains of the same specificity from a different rabbit. The activities of such recombinants could not be accounted for on the basis of additivity of binding capacities of the individual chains. This indicates that there are structural similarities, related to specificity, among the light chains of anti-DNP antibodies synthesized in different animals. In agreement with previous work, maximal activity of recombinants was observed when the chains were derived from the same animals.

Footnotes

This work was supported by grants from the National Institute of Allergy and Infectious Diseases (AI-06281) and the National Science Foundation (NSF GB-5424). Presented in part at the meeting of the Federated Societies for Experimental Biology and Medicine, Chicago, 1967.

² On leave from the Department of General Pathology, University of Naples. Public Health Service International Postdoctoral Research Fellow (FO5 TW 1101).

³ Research Career Award KO6-AI-2947.