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Wasting Disease Induced with Cortisol Acetate¹

II. Bacteriologic Studies

From the Department of Botany and Microbiology, Montana State University, Bozeman, Montana

Abstract

In the experiments reported here, the tissues and organs of neonatal mice treated with cortisol acetate were found to be infected with several species of bacteria apparently originating from the intestinal flora. Escherichia coli and Streptococcus faecalis were the predominant organisms isolated from the tissues of wasting mice. In studies designed to immunize newborn mice passively against organisms of the normal flora and their lipopolysaccharide (LPS) extracts, a weak protective effect was observed when a combined vaccine consisting of an LPS extract of Salmonella and S. faecalis bacterin was employed.

Footnotes

This investigation was supported by Research Grant no. 5 R01 AI 06552-02 from the National Institutes of Health.

² Present address: Department of Microbiology, University of Nebraska, Lincoln, Nebraska.