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The Journal of Immunology, 1968, 100: 654-658.
Copyright © 1968 by The American Association of Immunologists, Inc.
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Immune Response to Anti-Lymphocyte Globulin1

Hugo E. Jasin2, Seth H. Lourie3, H. L. F. Currey4 and Morris Ziff5

From the Department of Internal Medicine, Rheumatic Diseases Unit, The University of Texas Southwestern Medical School and the Dallas Veterans Administration Hospital, Dallas, Texas

Abstract

The appearance of antibodies to rabbit IgG in rats injected with the IgG fraction of rabbit anti-lymphocyte serum was examined. While 13 of 24 animals injected with ALG developed significant anti-rabbit IgG titers, only 2 rats of 18 injected with comparable amounts of normal rabbit IgG developed antibody, and in these it was present in relatively low titer. Evidence of immunosuppression was observed in the ALG treated animals in a reduction of antibody formation to sheep erythrocytes and a suppression of Freund's adjuvant-induced arthritis.

In a group of animals simultaneously injected with bovine {gamma}-globulin, the immune response to this protein was similar in both the experimental and control groups. The enhancement phenomenon observed, therefore, appeared to be specific for IgG with anti-lymphocyte activity.

Footnotes

This work was supported by United States Public Health Service Project Grant AM-09989 and United States Public Health Service Training Grant AM-05154.

2 Assistant Professor of Internal Medicine and Clinical Investigator, Veterans Administration.

3 Trainee in Arthritis, National Institute of Arthritis and Metabolic Diseases.

4 Trainee in Arthritis, National Institute of Arthritis and Metabolic Diseases. Present address: Department of Rheumatology, The London Hospital, London, England.

5 Career Investigator, United States Public Health Service.






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