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The Journal of Immunology, 1968, 100: 622-628.
Copyright © 1968 by The American Association of Immunologists, Inc.
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Homocytotropic Antibody Response in the Rat Infected with the Nematode, Nippostrongylus Brasiliensis

II. Characteristics of the Immune Response1

R. J. M. Wilson2 and K. J. Bloch3

From the Department of Tropical Public Health, Harvard School of Public Health, the Arthritis Unit of the Department of Medicine, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts

Abstract

In contrast to rats immunized with standard antigens and adjuvants which produce homocytotropic antibody in low titer only during the primary response, rats infected with N. brasiliensis larvae synthesized H.A. for prolonged periods and manifested a secondary response on reinfection. Washed peritoneal cells obtained from actively infected rats or normal peritoneal cells passively sensitized in vitro with serum from infected rats released histamine upon contact with worm antigens. The possible role of H.A. and H.A.-sensitized mast cells in host immunity to N. brasiliensis infection was discussed.

Footnotes

This publication is No. 446 of the Robert W. Lovett Memorial Group for the Study of Crippling Diseases, Harvard Medical School, at the Massachusetts General Hospital, Boston, Massachusetts.

This work was supported in part by Grant A100177 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service, The American Cancer Society, Massachusetts Division and the Medical Research Council, London.

2 Research Fellow, Harvard School of Public Health; on leave from National Institute of Research, Mill Hill, London.

3 Senior Investigator, Arthritis Foundation.






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