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Reversed Type Allergic Skin Reactions by Anti-E-Globulin Antibodies in Humans and Monkeys¹

From the Children's Asthma Research Institute and Hospital, Denver, Colorado

Abstract

The rabbit and guinea pig antisera specific for human E-globulin induced erythema-wheal reactions in normal human individuals and increased permeability of monkey skin capillaries, whereas the antibodies specific for other immunoglobulins did not. The minimum dose of rabbit anti-E-antibody to induce the skin reactions in both species was 10^-6 to 10^-5 µg N. The activity of the anti-E sera was removed by absorption of the antiserum with E-globulin. The results indicate that the skin reactions by anti-E-antibodies are reversed type allergic reactions, and that both normal human subjects and monkeys have E-globulin on the skin sites which are sensitized by human reaginic antibodies upon passive sensitization. A normal monkey serum and a chromatographic fraction of this serum neutralized the skin reactivity of the anti-E serum in the monkey, indicating that monkey serum contains "E-globulin," which has similar antigenic structure and physicochemical properties to human E-globulin.

Footnotes

This work was supported by Grants GB-4646 from the National Science Foundation and AI-04985 from the United States Public Health Service.

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