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Antigens of Rickettsia Prowazeki. II. Activity in Guinea Pigs and Experimental Vaccine Production

From the Department of Health, Education, and Welfare, United States Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Virology and Rickettsiology, Bethesda, Maryland

Abstract

Studies on the activity of fractions of Rickettsia prowazeki in guinea pigs revealed that protective antigens are found in cell wall, protoplasm and soluble antigen fractions. The soluble antigens released by ether treatment were the most active when compared on a dry weight basis with the other materials. The results of production of experimental vaccines by concentrating the rickettsiae before ether treatment showed that vaccines of excellent potency in the standard guinea pig assay could be obtained with a considerable reduction in contamination with egg material.