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Inhibition by Cardiolipin of the Antibody Response to Bacterial Antigens¹

From the Department of Bacteriology and Immunology and Pediatrics, State University of New York at Buffalo Medical School and Laboratories of Bacteriology, Children's Hospital and Roswell Park Memorial Institute, Buffalo, New York

Abstract

A study of the effects of eardiolipin on the immune response of rabbits to bacterial antigens revealed the following results. 1) Cardiolipin, when injected together with common bacterial antigens of enterobacteriaceae or of Gram-positive bacteria, inhibited the production of circulating antibodies, but did not interfere with immunologic priming. 2) Separate injections of antigen and inhibitor resulted in undiminished immune response. 3) The inhibitor did not affect the antigenic determinant of the antigens in vitro, nor did it interfere with antigen attachment to erythrocytes. 4) Cardiolipin did not inhibit the antibody response to O antigen. 5) The effects of cardiolipin on the immune response to common bacterial antigens resembled those produced by lipopolysaccharide and its lipoid A component.

Footnotes

¹ This study was aided by Research Grant no. 00658 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service.

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