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Genetic Control of the Antibody Response

III. Qualitative and Quantitative Characterization of the Antibody Response to (T,G)-A—L in CBA and C57 Mice¹

From the Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts

Abstract

A comparison of CBA and C57 antisera to (T,G)-A--L by means of quantitative precipitin curves, antigen-binding capacity assays and radioimmunoelectrophoresis has confirmed the previously described quantitative difference in the ability of these two strains of mice to respond to (T,G)-A--L, and has failed to show any qualitative correlation between the ability to respond and the immunoglobulin type of the antibodies made in the responding animal. In addition, in genetic crosses the ability to respond well was not correlated with the presence of the immunoglobulin allotype of the higher responding (C57) strain, indicating that the ability to respond is not linked to the structural genes coding for the Fc fragments of G₁-, G_2a-, G_2b- and A-immunoglobulins. It has also been shown that CBA and C57 mice differ in their ability to undergo a secondary response to aqueous antigen.

Footnotes

This investigation was supported by United States Public Health Service Grant No. AI-05691.

² Present address: Department of Medicine, Stanford University, School of Medicine, Palo Alto, California 94304.

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