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Delayed Hypersensitivity

II. Persistence and Conjugate Specificity of the Transfer Reaction¹

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut

Abstract

Transfer of sensitized cells to normal guinea pigs was used to study persistence and conjugate specificity of delayed hypersensitivity. Ability of donor cells to transfer delayed hypersensitivity persisted throughout the primary and secondary antibody responses of the donor animals. The skin reactions elicited in recipients of cells from hyperimmunized guinea pigs remained conjugate specific throughout the immune response.

Footnotes

This investigation was supported in part by National Science Foundation Grant GB 4190.

² Postdoctoral Trainee, United States Public Health Service Training Grant AI-271. Present address: Department of Medicine, University of Cincinnati Medical College, Cincinnati, Ohio.

³ Research Career Development Awardee, United States Public Health Service, National Institute of Allergy and Infectious Diseases, National Institutes of Health.