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Urinary Fc and F'c Fragments

Department of Medicine, State University of New York at Buffalo and The Buffalo General Hospital, 100 High Street, Buffalo, New York

Abstract

Fc fragment, indistinguishable from papain Fc, was demonstrated in concentrated normal human urine. F'c was found, in addition, in 20 urines tested. Urinary F'c was demonstrated to be antigenically deficient to urinary Fc, papain Fc and 7 S G, and identical to esterase induced F'c. Heterogeneity in size of urinary F'c was suggested by density gradient and analytical ultracentrifugation, polyacrylamide and immuno-electrophoresis and gel filtration. Urinary F'c may have a molecular weight range of 18,000 to 60,000: some urinary F'c has a sedimentation coefficient of 1·3 S.

On the basis of in vitro incubation experiments of radiolabeled 7 S G and papain Fc with normal human urine, it is concluded that native 7 S G is not easily degraded by urinary enzymes, whereas papain Fc breaks down to form the F'c fragment. The significance of these findings in relation to possible in vivo mechanisms is discussed.

Footnotes

Supported by a Buswell Fellowship awarded from The State University of New York at Buffalo.