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Hemagglutinin of Type 4 Adeno-Associated Satellite Virus¹

Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas

Abstract

The mixture of type 4 defective adeno-associated satellite virus and its simian helper adenovirus was found to have a high hemagglutinating (HA) activity, particularly with type O human erythrocytes at 4°C. This activity was inhibited by antiserum against the satellite but was virtually unchanged after treatment with adenovirus antiserum. Satellite-free simian adenovirus had a low level of HA activity itself, which could be completely inhibited by homologous adenovirus antiserum. Growth cycle studies showed that the increase of HA activity coincided with the rise of satellite infectivity. After density gradient centrifugation, bands which consisted of high concentrations of satellite particles alone also showed high HA activity. These results indicate that HA activity is a property of the type 4 adeno-associated satellite virus.

Footnotes

This work was supported in part by Public Health Service Grants CA-04600 from the National Cancer Institute and AI 05382 and 5 T1 AI 74 from the National Institute of Allergy and Infectious Diseases.

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