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The Journal of Immunology, 1968, 100: 34-38.
Copyright © 1968 by The American Association of Immunologists, Inc.
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Nephrotoxic Serum Nephritis in Mice with a Genetic Deficiency in Complement1

Lois H. Lindberg2 and Leon T. Rosenberg

Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California

Abstract

Complement-containing progeny from the hybridization of B10.D2-old line females with B10.D2-new line males were used to study the role of the complement system in immune tissue injury. Small differences in the severity of nephrotoxic serum nephritis were found following the injection of nephrotoxic serum which implicate the late acting complement components as intensifiers of tissue injury.

Footnotes

This investigation was supported by Public Health Service Research Grant no. AI-05316 and Training Grant no. 5 TI AI82-09.

2 National Science Foundation Science Faculty Fellow.






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