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The Journal of Immunology, 1968, 100: 15-23.
Copyright © 1968 by The American Association of Immunologists, Inc.
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A New Serum Factor in Normal Rabbits

IV. Occurrence in Neonatal Rabbit Sera1

William J. Mandy2, Marion E. Woolsey3 and F. B. Lewis

Department of Microbiology, The University of Texas, Austin, Texas, and the Department of Medicine, Mt. Sinai Hospital, and the University of Minnesota School of Medicine, Minneapolis, Minnesota

Abstract

Homoreactant in rabbits has been shown to be passively transmitted from mother to fetus, thus fulfilling another criterion of its immunoglobulin nature. Newly synthesized HR began to appear in the newborn rabbit sera immediately after the disappearance of maternal HR, i.e., 4 to 5 weeks after parturition.

Early HR characterized as a {gamma}M-globulin by 2-ME sensitivity and DEAE-cellulose chromatography was actively synthesized by the newborn rabbit only between the ages of 4 and 10 weeks. This was followed by the continued synthesis of a 2-ME resistant {gamma}G-globulin HR. This constitutes the first observation of an apparent 19 S to 7 S transition in the synthesis of a natural antibody.

Both the 2-ME susceptible and 2-ME resistant forms of HR were directed to determinants which are otherwise buried in the intact {gamma}G-globulin molecule and exposed by digestion with papain.

Footnotes

This study was supported by the United States Public Health Service Grants AI-07184-02 and AI-06221. This paper was presented in part at the annual meeting of the American Association of Microbiologists, New York City, May 1, 1967.

2 Recipient of a United States Public Health Career Development Award.

3 Recipient of a United States Public Health Predoctoral Fellowship.






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